Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+.

Title

Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+.

Creator

Lambert N A; Harrison N L; Teyler T J

Publisher

Brain research

Date

1991
1991-05

Description

The mechanism of disinhibition produced by (+/-)-baclofen was studied using intracellular recording in area CA1 of rat hippocampal slices. Baclofen reversibly depressed monosynaptic IPSPs evoked by direct activation of interneurons in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). Ba2+ prevented baclofen-induced hyperpolarization of pyramidal neurons but not depression of monosynaptic IPSPs by baclofen. Baclofen reversibly depressed monosynaptic IPSPs when applied close to the recording site, but was ineffective when applied close to the stimulating site in stratum radiatum. These results suggest that baclofen disinhibits pyramidal neurons in area CA1 of the rat hippocampus by activating receptors on the terminals of inhibitory neurons that are coupled to a Ba(2+)-insensitive effector mechanism.

Subject

Animals; Rats; In Vitro Techniques; Quinoxalines/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Hippocampus/*drug effects; Evoked Potentials/drug effects; Baclofen/antagonists & inhibitors/*pharmacology; Barium/*pharmacology; Drug Resistance/physiology; Interneurons/drug effects; Neural Inhibition/drug effects; Receptors; GABA-A/*drug effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

349–352

Issue

2

Volume

547

Citation

Lambert N A; Harrison N L; Teyler T J, “Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+.,” NEOMED Bibliography Database, accessed May 11, 2021, https://neomed.omeka.net/items/show/5500.

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