Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142.

Title

Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142.

Creator

Leidenheimer N J; Schechter M D

Publisher

Pharmacology, biochemistry, and behavior

Date

1991
1991-03

Description

Male rats were trained to discriminate the stimulus properties of the beta-carbolines 1,2,3,4-tetrahydro-beta-carboline (THBC) (15.0 mg/kg) or FG 7142 (5.0 mg/kg) from vehicle in a two-lever, food-motivated operant task. Consistent with the serotonergic properties of THBC, administration of the 5HT1B agonists TFMPP and mCPP to THBC-trained rats resulted in THBC-appropriate responding. Norharmane, a beta-carboline metabolite of THBC, also mimicked the THBC discriminative stimulus. In contrast, the benzodiazepine receptor partial inverse agonist FG 7142, the anxiogenic/convulsant pentylenetetrazole (PTZ), two physiological stressors and the alpha 2 adrenergic antagonists yohimbine and idazoxan failed to produce THBC-appropriate responding. In the FG 7142-trained rats, THBC and norharmane dose-dependently mimicked the FG 7142 discriminative stimulus. This generalization was not based upon the serotonergic properties of THBC and norharmane since administration of the serotonin agonist mCPP to FG

Subject

Male; Animals; Rats; Discrimination Learning/*drug effects; Avoidance Learning/drug effects; Carbolines/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Generalization; Stimulus/*drug effects; GABA-A/*drug effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

519–525

Issue

3

Volume

38

Citation

Leidenheimer N J; Schechter M D, “Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142.,” NEOMED Bibliography Database, accessed October 23, 2021, https://neomed.omeka.net/items/show/5513.

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