Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus.

Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus.

Little Z; Grover L M; Teyler T J

Neuroscience letters

1995

1995-12

The necessity of metabotropic glutamate receptors (mGluRs) in the induction of long-term potentiation (LTP) has recently been questioned. We examined the effect of (R,S)-alpha-methyl-4-caboxyphenylglycine (MCPG), a selective mGluR antagonist, on two independent forms of LTP. One form induced by a 25 Hz/1 s tetanus is solely N-methyl-D-aspartate (NMDA) receptor-dependent. The other form induced by four 200 Hz/0.5 s bursts in the presence of APV is NMDA receptor-independent. In both paradigms the presence of MCPG prevented the induction of LTP by afferent activation.

Animals; Rats; Electric Stimulation; In Vitro Techniques; Electrophysiology; Excitatory Amino Acid Antagonists/*pharmacology; Long-Term Potentiation/*drug effects; Hippocampus/drug effects/*physiology; Benzoates/*pharmacology; Calcium Channels/drug effects/metabolism/physiology; Glycine/*analogs & derivatives/pharmacology; Ion Channel Gating/drug effects; Receptors; Metabotropic Glutamate/*antagonists & inhibitors

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