Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.
Title
Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.
Creator
Pehek E A; Schechter M D
Publisher
Pharmacology, biochemistry, and behavior
Date
1990
1990-06
Description
The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance) to subsequent cathine and this effect developed and dissipated rapidly. Thus, different dose-response curves were generated depending upon whether cathine or vehicle was administered the day before testing. The development of tolerance also shortened cathine's time course of action and enhanced the ability of haloperidol to antagonize the cathine cue. These results suggest caution in interpreting effects produced by intermittent drug injection schedules.
Subject
Male; Animals; Rats; Drug Administration Schedule; Drug Tolerance; Psychotropic Drugs/*pharmacology; Haloperidol/pharmacology; Alkaloids/*pharmacology; *Discrimination (Psychology)/drug effects; Catha; Domperidone/pharmacology; Phenylpropanolamine/antagonists & inhibitors/*pharmacology; Plant Extracts/analysis; Inbred Strains
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Pehek E A; Schechter M D, “Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.,” NEOMED Bibliography Database, accessed April 25, 2025, https://neomed.omeka.net/items/show/5565.