Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.

Title

Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.

Creator

Pehek E A; Schechter M D

Publisher

Pharmacology, biochemistry, and behavior

Date

1990
1990-06

Description

The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance) to subsequent cathine and this effect developed and dissipated rapidly. Thus, different dose-response curves were generated depending upon whether cathine or vehicle was administered the day before testing. The development of tolerance also shortened cathine's time course of action and enhanced the ability of haloperidol to antagonize the cathine cue. These results suggest caution in interpreting effects produced by intermittent drug injection schedules.

Subject

Male; Animals; Rats; Drug Administration Schedule; Drug Tolerance; Psychotropic Drugs/*pharmacology; Haloperidol/pharmacology; Alkaloids/*pharmacology; *Discrimination (Psychology)/drug effects; Catha; Domperidone/pharmacology; Phenylpropanolamine/antagonists & inhibitors/*pharmacology; Plant Extracts/analysis; Inbred Strains

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

267–271

Issue

2

Volume

36

Citation

Pehek E A; Schechter M D, “Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.,” NEOMED Bibliography Database, accessed May 14, 2021, https://neomed.omeka.net/items/show/5565.

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