A critical period for long-term potentiation in the developing rat visual cortex.

Title

A critical period for long-term potentiation in the developing rat visual cortex.

Creator

Perkins A T 4th; Teyler T J

Publisher

Brain research

Date

1988
1988-01

Description

The in vitro rodent visual cortical slice preparation demonstrates a critical period for long-term potentiation (LTP). Current source density (CSD) analysis reveals peak potentiation of both supra-(layers II-III) and infragranular (layers V) layers of visual cortex during the second postnatal week following stimulation of the subadjacent white matter. By day 30 both the supra- and infragranular CSD sinks show only minimal potentiation. In adults there is no change in supragranular response but infragranular layers reveal 177% potentiation. Therefore, we conclude that rodent visual cortex displays a critical period for maximum plasticity of both supra and infra-granular layers. Supragranular visual cortex plasticity ends by day 30 whereas infragranular layers retain plastic qualities into adulthood.

Subject

Animals; Rats; Aging; Electric Stimulation; In Vitro Techniques; Neuronal Plasticity; Visual Cortex/*growth & development/physiology; Newborn

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

222–229

Issue

1

Volume

439

Citation

Perkins A T 4th; Teyler T J, “A critical period for long-term potentiation in the developing rat visual cortex.,” NEOMED Bibliography Database, accessed May 7, 2021, https://neomed.omeka.net/items/show/5568.

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