Temporal differences in behavioral effect of fenfluramine and norfenfluramine.

Title

Temporal differences in behavioral effect of fenfluramine and norfenfluramine.

Creator

Schechter M D

Publisher

Pharmacology, biochemistry, and behavior

Date

1990
1990-03

Description

Ten male rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-reinforced (fixed-ratio 10 schedule) two-lever operant task. Once learned, the fenfluramine stimulus was dose-dependent (ED50 = 0.8 mg/kg) and stereoselective with the d-isomer (ED50 = 0.6 mg/kg) approximate twice as potent as the l-isomer (ED50 = 1.2 mg/kg). Time-course data indicate that the fenfluramine metabolite norfenfluramine produces a significantly faster onset and longer duration of action than does the parent compound. The results suggest that both stereoisomers of fenfluramine have discriminative stimulus properties and that the fenfluramine metabolite, norfenfluramine, contributes to the discriminative stimulus properties of the parent drug.

Subject

Male; Animals; Rats; Behavior; Stereoisomerism; Injections; Discrimination Learning/*drug effects; Fenfluramine/*analogs & derivatives/*pharmacology; Norfenfluramine/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Intraperitoneal; Animal/*drug effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

527–531

Issue

3

Volume

35

Citation

Schechter M D, “Temporal differences in behavioral effect of fenfluramine and norfenfluramine.,” NEOMED Bibliography Database, accessed May 16, 2021, https://neomed.omeka.net/items/show/5629.

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