Use of TFMPP stimulus properties as a model of 5-HT1B receptor activation.

Use of TFMPP stimulus properties as a model of 5-HT1B receptor activation.

Schechter M D

Pharmacology, biochemistry, and behavior

1988

1988-09

Recent evidence indicates that when 1-(3-trifluoromethylphenyl)piperazine (TFMPP) is used as a training drug in the drug discrimination paradigm it produces a stimulus effect that is site-selective at the 5-HT1B receptor. The present study sought to employ this procedure in order to assess the similarity of novel agents to TFMPP. First, rats were trained to reliably discriminate between the stimulus properties of intraperitoneally administered 1.0 mg/kg TFMPP and its vehicle. Following the acquisition of this discrimination, administration of various doses of TFMPP produced a typical dose-response relationship with an ED50 of 0.27 mg/kg. Rats were subsequently tested with another 5-HT1B specific agonist

Male; Animals; Rats; Serotonin/pharmacology; Pharmaceutical Vehicles; Discrimination Learning/*drug effects; Norfenfluramine/pharmacology; Piperazines/*pharmacology; Dose-Response Relationship; Drug; Receptors; Biological; Models; Serotonin/*drug effects/physiology

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

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