The development of long-term potentiation in hippocampus and neocortex.

Title

The development of long-term potentiation in hippocampus and neocortex.

Creator

Teyler T J; Perkins A T 4th; Harris K M

Publisher

Neuropsychologia

Date

1989
1989

Description

The development of long-term potentiation (LTP), an enduring alteration in synaptic efficacy following afferent activation, was examined in CA1 hippocampus and primary visual cortex of rat. Both regions show little LTP prior to postnatal day 5, demonstrate a maximal potentiated response around postnatal day 15, and a subsequent decline to adult levels. These results are discussed with respect to the underlying mechanism of action and behavioral significance of these critical-period phenomena.

Subject

Female; Animals; Neurons/physiology; Rats; Electric Stimulation; *Synaptic Transmission; Aging/*physiology; Synapses/physiology; Hippocampus/*physiology; Cerebral Cortex/*physiology; Memory/*physiology; Evoked Potentials; Mental Recall/*physiology; Visual Cortex/physiology; Visual Pathways/physiology; Inbred Strains

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

31–39

Issue

1

Volume

27

Citation

Teyler T J; Perkins A T 4th; Harris K M, “The development of long-term potentiation in hippocampus and neocortex.,” NEOMED Bibliography Database, accessed September 26, 2021, https://neomed.omeka.net/items/show/5667.

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