The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

Title

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

Creator

Yamamoto B K; Spanos L J

Publisher

European journal of pharmacology

Date

1988
1988-03

Description

The effects of the recently classified Schedule I amphetamine analog, 3,4-methylenedioxymethamphetamine [+/-)-MDMA) on caudate and nucleus accumbens dopamine release and metabolism were studied by in vivo voltammetry and HPLC with electrochemical detection. Monitored over a 3 h period, the magnitude of increase in dopamine release and the onset of effect were dose-dependent and similar for both brain areas following the 2.5 and 5 mg/kg dose of the drug. However, responses were different for these brain regions using 10 mg/kg of MDMA; the magnitude of increase was greater and the onset of effect more immediate in caudate. Analysis of dopamine and DOPAC tissue content in both caudate and nucleus accumbens verified the voltammetry results. This study provides the first evidence that MDMA induces dopamine release in vivo and that this effect is region, time- and dose-dependent.

Subject

Male; Animals; Rats; Dopamine/*metabolism; Consciousness; Amphetamines/*pharmacology; Brain/drug effects/metabolism; Caudate Nucleus/drug effects/metabolism; Nucleus Accumbens/drug effects/metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

195–203

Issue

2

Volume

148

Citation

Yamamoto B K; Spanos L J, “The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.,” NEOMED Bibliography Database, accessed September 18, 2021, https://neomed.omeka.net/items/show/5715.

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