The Association of Acetaminophen and Asthma Prevalence and Severity.

The Association of Acetaminophen and Asthma Prevalence and Severity.

McBride John T

Pediatrics

2011

2011-12

The epidemiologic association between acetaminophen use and asthma prevalence and severity in children and adults is well established. A variety of observations suggest that acetaminophen use has contributed to the recent increase in asthma prevalence in children: (1) the strength of the association; (2) the consistency of the association across age, geography, and culture; (3) the dose-response relationship; (4) the timing of increased acetaminophen use and the asthma epidemic; (5) the relationship between per-capita sales of acetaminophen and asthma prevalence across countries; (6) the results of a double-blind trial of ibuprofen and acetaminophen for treatment of fever in asthmatic children; and (7) the biologically plausible mechanism of glutathione depletion in airway mucosa. Until future studies document the safety of this drug, children with asthma or at risk for asthma should avoid the use of acetaminophen. [ABSTRACT FROM AUTHOR]

Child; United States; Prevalence; UNITED States; ACETAMINOPHEN; ASTHMA; ASTHMA risk factors; CHILDREN; DISEASE prevalence; SEVERITY of illness index; Severity of Illness; Acetaminophen – Adverse Effects – In Infancy and Childhood; Asthma – Epidemiology – In Infancy and Childhood; Asthma – Risk Factors – In Infancy and Childhood

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1181–1185

6

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