The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: A pilot study.

Title

The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: A pilot study.

Creator

Nugent Nicole R; Christopher Norman C; Crow John P; Browne Lorin; Ostrowski Sarah; Delahanty Douglas L

Publisher

Journal of Traumatic Stress

Date

2010
2010-04

Description

Initial research supports the use of propranolol to prevent posttraumatic stress disorder (PTSD); research has not examined pharmacological prevention for children. Twenty-nine injury patients (ages 10–18 years old) at risk for PTSD were randomized to a double-blind 10-day trial of propranolol or placebo initiated within 12 hours postadmission. Six-week PTSD symptoms and heart rate were assessed. Although intent-to-treat analyses revealed no group differences, findings supported a significant interaction between gender and treatment in medication-adherent participants, ΔR2 = .21. Whereas girls receiving propranolol reported more PTSD symptoms relative to girls receiving placebo, ΔR2 = .44, boys receiving propranolol showed a nonsignificant trend toward fewer PTSD symptoms than boys receiving placebo, ΔR2 = .32. Findings inform gender differences regarding pharmacological PTSD prevention in youth. [ABSTRACT FROM AUTHOR]

Subject

TREATMENT of post-traumatic stress disorder; STRESS (Psychology); GENDER differences (Psychology); CHILDREN'S injuries; BLIND experiment; PHARMACOLOGY; PLACEBOS (Medicine); PROPRANOLOL

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

282–287

Issue

2

Volume

23

Citation

Nugent Nicole R; Christopher Norman C; Crow John P; Browne Lorin; Ostrowski Sarah; Delahanty Douglas L, “The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: A pilot study.,” NEOMED Bibliography Database, accessed January 18, 2021, https://neomed.omeka.net/items/show/5744.

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