NUT Midline Carcinoma: A Rare Malignancy.

Title

NUT Midline Carcinoma: A Rare Malignancy.

Creator

Al Diffalha Sameer; Al Aukla Nidal; Hasan Saleh; Dickinson Shohreh; Khalil Farah

Publisher

Cancer Control: Journal of the Moffitt Cancer Center

Date

2017
2017-04

Description

Nuclear protein of the testis (NUT) midline carcinoma can present in the head, neck, and mediastinum. In general, it presents in young adult men and has a poor prognosis. We report on a case of NUT midline carcinoma of the mediastinum in a man 27 years of age without any prior malignancy. Due to the location of the tumor, mediastinal lymphoma and germ cell tumor were initially considered; however, immunohistochemistry was performed using NUT antibody that revealed it to be NUT midline carcinoma. Although guidelines exist for squamous cell carcinoma of the head, neck, and mediastinum, no such specific guidelines are available for NUT midline carcinoma, which looks morphologically similar to squamous cell carcinoma but behaves more aggressively and carries a poor prognosis.

Subject

Adult; Male; Carcinoma; Proteins – Metabolism; Carcinoma – Diagnosis; Carcinoma – Metabolism; Mediastinal Neoplasms – Diagnosis; Mediastinal Neoplasms – Metabolism; Nuclear Proteins – Metabolism; Squamous Cell – Diagnosis; Squamous Cell – Metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

202–206

Issue

2

Volume

24

Citation

Al Diffalha Sameer; Al Aukla Nidal; Hasan Saleh; Dickinson Shohreh; Khalil Farah, “NUT Midline Carcinoma: A Rare Malignancy.,” NEOMED Bibliography Database, accessed March 3, 2021, https://neomed.omeka.net/items/show/5832.

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