Delivery Systems as Vital Tools in Drug Repurposing.

Title

Delivery Systems as Vital Tools in Drug Repurposing.

Creator

Czech Tori; Lalani Reza; Oyewumi Moses O

Publisher

AAPS PharmSciTech

Date

2019
2019-02

Description

The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs.

Subject

Humans; Nanoparticles; *Drug Delivery Systems; Nanoparticles; Tissue Distribution; combination drugs; *Drug Delivery Systems; drug development; nanocarriers; *Drug Repositioning; Drug Carriers

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

116-116

Issue

3

Volume

20

Citation

Czech Tori; Lalani Reza; Oyewumi Moses O, “Delivery Systems as Vital Tools in Drug Repurposing.,” NEOMED Bibliography Database, accessed January 22, 2021, https://neomed.omeka.net/items/show/6318.

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