TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review).

TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review).

Mbimba Thomas; Hussein Nazar J; Najeed Ayesha; Safadi Fayez F

International journal of molecular medicine

2018

2018-12

Trafficking protein particle complex 9 (TRAPPC9) is a protein subunit of the transport protein particle II (TRAPPII), which has been reported to be important in the trafficking of cargo from the endoplasmic reticulum (ER) to the Golgi, and in intraGolgi and endosometoGolgi transport in yeast cells. In mammalian cells, TRAPPII has been shown to be important in Golgi vesicle tethering and intraGolgi transport. TRAPPC9 is considered to be a novel molecule capable of modulating the activation of nuclear factorkappaB (NFkappaB). Mutations in TRAPPC9 have been linked to a rare consanguineous hereditary form of mental retardation, as part of the NFkappaB pathways. In addition, TRAPPC9 has been reported to be involved in breast and colon cancer and liver diseases. The present review highlights the most recent publications on the structure, expression and function of TRAPPC9, and its association with various human diseases.

Humans; Animals; Protein Binding; Gene Expression Regulation; Structure-Activity Relationship; Protein Transport; *Signal Transduction; *Disease Susceptibility; Carrier Proteins/chemistry/genetics/*metabolism; Protein Interaction Domains and Motifs

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2991-2997

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