Bile Acids as Metabolic Regulators and Nutrient Sensors
Title
Bile Acids as Metabolic Regulators and Nutrient Sensors
Creator
Chiang John Y L; Ferrell Jessica M
Publisher
Annual Review of Nutrition
Date
2019
2019-04
Description
Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors that regulate lipid and energy metabolism. The brain-gut-liver axis plays an essential role in maintaining overall glucose, bile, and immune homeostasis. Fasting and feeding transitions alter nutrient content in the gut, which influences bile acid composition and pool size. In turn, bile acid signaling mediates lipid and glucose use and protection against inflammation. Altered bile acid metabolism resulting from gene mutations, high-fat diets, alcohol, or circadian disruption can contribute to cholestatic and inflammatory diseases, diabetes, and obesity. Bile acids and their derivatives are valuable therapeutic agents for treating these inflammatory metabolic diseases. Expected final online publication date for the Annual Review of Nutrition Volume 39 is August 21, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Chiang John Y L; Ferrell Jessica M, “Bile Acids as Metabolic Regulators and Nutrient Sensors,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/6373.