GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABA(A)R gamma(1) subunit during aging

Title

GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABA(A)R gamma(1) subunit during aging

Creator

Robinson L C; Barat O; Mellott J G

Publisher

Neurobiology of Aging

Date

2019
2019-08

Description

Age-related hearing loss may result, in part, from declining levels of gamma-amino butyric acid (GABA) in the aging inferior colliculus (IC). An upregulation of the GABA(A)R gamma(1) subunit, which has been shown to increase sensitivity to GABA, occurs in the aging IC. We sought to determine whether the upregulation of the GABA(A)R gamma(1) subunit was specific to GABAergic or glutamatergic IC cells. We used immunohistochemistry for glutamic acid decarboxylase and the GABA(A)R gamma(1) subunit at 4 age groups in the IC of Fisher Brown Norway rats. The percentage of somas that expressed the gamma(1) subunit and the number of subunits on each soma were quantified. Our results show that GABAergic and glutamatergic IC cells increasingly expressed the gamma(1) subunit from young age until expression peaked during middle age. At old age (similar to 77% of life span), the number of GABA(A)R gamma(1) subunits per cell sharply decreased for both cell types. These results, along with previous studies, suggest inhibitory and excitatory IC circuits may express the GABA(A)R gamma(1) subunit in response to the age-related decline of available GABA. Published by Elsevier Inc.

Subject

Age-related hearing loss; age-related-changes; amino-acids; auditory-cortex; binding; brain; fischer-344 rat; GABA(A) receptor; GABA(A)R gamma(1) subunit; GABAergic; Geriatrics & Gerontology; Glutamatergic; glutamic-acid decarboxylase; hearing-loss; Inferior colliculus; Neurons; Neurosciences & Neurology; primary; receptive-fields

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

99-110

Volume

80

Citation

Robinson L C; Barat O; Mellott J G, “GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABA(A)R gamma(1) subunit during aging,” NEOMED Bibliography Database, accessed January 26, 2021, https://neomed.omeka.net/items/show/6487.

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