Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.

Title

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.

Creator

Ferrell Jessica M; Chiang John Y L

Publisher

Diabetes & Metabolism Journal

Date

2019
2019-06

Description

Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and nonalcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease. [ABSTRACT FROM AUTHOR]

Subject

BILE acids; Bile acids and salts; cholesterol 7-alpha-hydroxylase; Cytoplasmic and Nuclear; Endocrinology & Metabolism; FARNESOID X receptor; farnesoid-x-receptor; FATTY liver; fatty liver-disease; G protein coupled receptors; G-protein-coupled; Gastrointestinal microbiome; growth-factor 19; gut microbiota; hepatic steatosis; improves insulin sensitivity; liver disease; metabolic; Non-alcoholic fatty; Non-alcoholic Fatty Liver Disease; nuclear; receptor; Receptors; serum fgf21 levels; syndrome

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

257-272

Issue

3

Volume

43

Citation

Ferrell Jessica M; Chiang John Y L, “Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.,” NEOMED Bibliography Database, accessed January 16, 2021, https://neomed.omeka.net/items/show/6530.

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