Trisomy 8 is a characteristic finding in pleuropulmonary blastoma
Title
Trisomy 8 is a characteristic finding in pleuropulmonary blastoma
Creator
Novak R; Dasu S; Agamanolis D; Herold W; Malone J; Waterson J
Publisher
Pediatric Pathology & Laboratory Medicine
Date
1997
1997-01
Description
The cytogenetic findings in pleuropulmonary blastoma (PPB) have not been widely studied and reported and are of interest in view of the implications that PPB has for additional tumors in the patient and the patient's relatives. Using standard tumor cytogenetic methodology, we investigated three cases of PPB encountered in our institution over a 5-year period. Trisomy 8 was the only karyotypic abnormality in a localized type 2 PPB and was present with other abnormalities in another type 2 PPB and a massive type 3 PPB. Review of the literature yielded three additional karyotyped PPBs; all had trisomy 8 as part of the abnormalities detected. Trisomy 8 appears to be a characteristic of PPB and may be related to the development of PPB and related tumors.
Subject
aberrations; childhood; chromosomal-abnormalities; mosaicism; Pathology; Pediatrics; pleuropulmonary blastoma; pulmonary blastoma; trisomy 8; tumors
Identifier
Format
Journal Article
URL Address
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Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
99-103
Issue
1
Volume
17
Citation
Novak R; Dasu S; Agamanolis D; Herold W; Malone J; Waterson J, “Trisomy 8 is a characteristic finding in pleuropulmonary blastoma,” NEOMED Bibliography Database, accessed April 18, 2024, https://neomed.omeka.net/items/show/6661.