Fibrillary glomerulonephritis with hepatitis C viral infection and hypocomplementemia

Fibrillary glomerulonephritis with hepatitis C viral infection and hypocomplementemia

Ray S; Rouse K; Appis A; Novak R; Haller N A

Renal Failure

2008

2008

Fibrillary glomerulonephritis (FGN) is a relatively rare cause of renal disease, found in only 0.6-1.5% of native renal biopsies. The pathogenesis of FGN is not well described, and very few associations with disease processes other than hepatitis C virus (HCV) have been made. We describe a case that provides evidence in support of the FGN-HCV association, as well as introduces the association of FGN-HCV and hypocomplementemia. The case is a 53-year-old African-American female demonstrating a classical presentation of FGN complicated by a concomitant HCV infection. Treating an HCV infection with alpha-interferon has been shown to result in subsequent improvement in the nephrotic syndrome and renal function. However, this patient is unique in that she is complicated with hypocomplementemia, creating a complex treatment situation.

deposits; entity; features; fibrillary glomerulonephritis; hepatitis C infection; hypocomplementemia; immunofluorescence; immunotactoid glomerulopathy; Urology & Nephrology

Journal Article

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759-762

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