Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals

Title

Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals

Creator

Riddick D S; Lee C; Bhathena A; Timsit Y E; Cheng P Y; Morgan E T; Prough R A; Ripp S L; Miller K K M; Jahan A; Chiang J Y L

Publisher

Drug Metabolism and Disposition

Date

2004
2004-04

Description

This article is an invited report of a symposium sponsored by the Division for Drug Metabolism of the American Society for Pharmacology and Experimental Therapeutics held at Experimental Biology 2003 in San Diego, California, April 11 - 15, 2003. Several members of the cytochrome P450 (P450) superfamily are induced after exposure to a variety of chemical signals, and we have gained considerable mechanistic insight into these processes over the past four decades. In addition, the expression of many P450s is suppressed in response to various endogenous and exogenous chemicals; however, relatively little is known about the molecular mechanisms involved. The goal of this symposium was to critically examine our current understanding of molecular mechanisms involved in transcriptional suppression of CYP genes by endogenous and exogenous chemicals. Specific examples were drawn from the following chemical categories: polycyclic and halogenated aromatic hydrocarbon environmental toxicants, inflammatory mediators, the endogenous sterol dehydroepiandrosterone and peroxisome proliferators, and bile acids. Multiple molecular mechanisms are involved in transcriptional suppression, and these processes often involve rather complex cascades of transcription factors and other regulatory proteins. Mechanistic studies of CYP gene suppression can enhance our understanding of how organisms respond to xenobiotics as well as to perturbations in endogenous chemicals involved in maintaining homeostasis.

Subject

bile acid; cholesterol 7 alpha-hydroxylase; cyp2c11 gene; cyp7a1 transcription; down-regulation; messenger-rna; nuclear receptor; Pharmacology & Pharmacy; polycyclic aromatic-hydrocarbons; pregnane X receptor; rat-liver

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

367-375

Issue

4

Volume

32

Citation

Riddick D S; Lee C; Bhathena A; Timsit Y E; Cheng P Y; Morgan E T; Prough R A; Ripp S L; Miller K K M; Jahan A; Chiang J Y L, “Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals,” NEOMED Bibliography Database, accessed October 20, 2021, https://neomed.omeka.net/items/show/6878.

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