Initial results of the FUSION-X-US prototype combining 3D automated breast ultrasound and digital breast tomosynthesis

Title

Initial results of the FUSION-X-US prototype combining 3D automated breast ultrasound and digital breast tomosynthesis

Creator

Schaefgen B; Heil J; Barr R G; Radicke M; Harcos A; Gomez C; Stieber A; Hennigs A; Von Au A; Spratte J; Rauch G; Rom J; Schutz F; Sohn C; Golatta M

Publisher

European Radiology

Date

2018
2018-06

Description

To determine the feasibility of a prototype device combining 3D-automated breast ultrasound (ABVS) and digital breast tomosynthesis in a single device to detect and characterize breast lesions. In this prospective feasibility study, the FUSION-X-US prototype was used to perform digital breast tomosynthesis and ABVS in 23 patients with an indication for tomosynthesis based on current guidelines after clinical examination and standard imaging. The ABVS and tomosynthesis images of the prototype were interpreted separately by two blinded experts. The study compares the detection and BI-RADSA (R) scores of breast lesions using only the tomosynthesis and ABVS data from the FUSION-X-US prototype to the results of the complete diagnostic workup. Image acquisition and processing by the prototype was fast and accurate, with some limitations in ultrasound coverage and image quality. In the diagnostic workup, 29 solid lesions (23 benign, including three cases with microcalcifications, and six malignant lesions) were identified. Using the prototype, all malignant lesions were detected and classified as malignant or suspicious by both investigators. Solid breast lesions can be localized accurately and fast by the Fusion-X-US system. Technical improvements of the ultrasound image quality and ultrasound coverage are needed to further study this new device. The prototype combines tomosynthesis and automated 3D-ultrasound (ABVS) in one device. It allows accurate detection of malignant lesions, directly correlating tomosynthesis and ABVS data. The diagnostic evaluation of the prototype-acquired data was interpreter-independent. The prototype provides a time-efficient and technically reliable diagnostic procedure. The combination of tomosynthesis and ABVS is a promising diagnostic approach.

Subject

Breast; cancer; cancer; combination; dense breasts; future; hhus; Mammography; Multimodal Imaging; Nuclear Medicine & Medical Imaging; program; Radiology; screening mammography; therapy; Ultrasonography; volume; women

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

2499-2506

Issue

6

Volume

28

Citation

Schaefgen B; Heil J; Barr R G; Radicke M; Harcos A; Gomez C; Stieber A; Hennigs A; Von Au A; Spratte J; Rauch G; Rom J; Schutz F; Sohn C; Golatta M, “Initial results of the FUSION-X-US prototype combining 3D automated breast ultrasound and digital breast tomosynthesis,” NEOMED Bibliography Database, accessed March 3, 2021, https://neomed.omeka.net/items/show/7061.

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