Phentermine plus fenfluramine produce cocaine-like discriminative cues
Title
Phentermine plus fenfluramine produce cocaine-like discriminative cues
Creator
Schechter M D; McBurney D
Publisher
Life Sciences
Date
1996
1996-10
Description
Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine + fenfluramine. Once having reached criterion performance, these rats were tested with lower doses of cocaine and generated a typical dose-response curve allowing for calculation of an ED(50) value: 2.798 mg/kg. Testing of phentermine in doses of 1.25-5.0 mg/kg indicated generalization with the highest dose producing 80% cocaine-appropriate responding and allowing for an ED(50) value of 2.356 mg/kg. When the phentermine doses were tested in combination 2.0 mg/kg fenfluramine, however, there was an increase in the discriminability of the highest phentermine dose and a slight decrease in the ED(50) value of the combination. Thus, administration of phentermine + fenfluramine, having both dopamine-releasing and serotonin-releasing properties, respectively, may mimic the neurochemical activity by which cocaine acts in the central nervous system and may possibly allow for cocaine-like effects as these two drugs see increased use in obesity control.
Subject
analogs; cocaine; combinations; drug discrimination; fenfluramine; Pharmacology & Pharmacy; phentermine; receptors; Research & Experimental Medicine; serotonin; stimulus properties
Identifier
Format
Journal Article
URL Address
Search for Full-text
Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
PL303-PL308
Issue
20
Volume
59
Citation
Schechter M D; McBurney D, “Phentermine plus fenfluramine produce cocaine-like discriminative cues,” NEOMED Bibliography Database, accessed March 28, 2024, https://neomed.omeka.net/items/show/7100.