Amphiphilic networks .10. Diffusion of glucose and insulin (and nondiffusion of albumin) through amphiphilic membranes

Title

Amphiphilic networks .10. Diffusion of glucose and insulin (and nondiffusion of albumin) through amphiphilic membranes

Creator

Shamlou S; Kennedy J P; Levy R P

Publisher

Journal of Biomedical Materials Research

Date

1997
1997-05

Description

Select semipermeable amphiphilic membranes have been prepared and their diffusional characteristics for glucose, insulin, and albumin investigated. The membranes were prepared by cast copolymerization of a hydrophilic monomer (i.e., N,N-dimethyl acrylamide, or N,N-dimethylaminoethyl methacrylate) with the hydrophobic crosslinker methacrylate-ditelechelic polyisobutylene. The products have sufficient mechanical properties for the fabrication of swollen membranes, sheets, tubes, etc. Membranes have been identified which allowed the rapid simultaneous countercurrent diffusion of glucose (M-n = 180 Da) and insulin (M-n = 5733 Da) but did not allow albumin (Mn similar to 60,000 Da) to pass. Evidently, the effective molecular weight cutoff point of these membranes is in the 6-60-KDa range. (C) 1997 John Wiley & Sons, Inc.

Subject

cells; Drug Release; Engineering; Materials Science; pancreas; sequential co-polymers; telechelic polymers; transfer agents inifers

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

157-163

Issue

2

Volume

35

Citation

Shamlou S; Kennedy J P; Levy R P, “Amphiphilic networks .10. Diffusion of glucose and insulin (and nondiffusion of albumin) through amphiphilic membranes,” NEOMED Bibliography Database, accessed June 20, 2021, https://neomed.omeka.net/items/show/7143.

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