Lyotropic chromonic liquid crystals for biological sensing applications

Title

Lyotropic chromonic liquid crystals for biological sensing applications

Creator

Shiyanovskii S V; Lavrentovich O D; Schneider T; Ishikawa T; Smalyukh I I; Woolverton C J; Niehaus G D; Doane K J

Publisher

Molecular Crystals and Liquid Crystals

Date

2005
2005

Description

We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the particle's size. The effect allows us to propose a real-time microbial sensor based on a lyotropic chromonic LC (LCLC) that detects and amplifies the presence of immune complexes. A cassette is filled with LCLC, antibody, and antigen-bearing particles. Small and isolated particles cause no macroscopic distortions of the uniformly aligned LCLC. Upon antibody-antigen binding, the growing immune complexes.

Subject

biosensor; cells; Chemistry; chromonics; Crystallography; ligand-receptor binding; liquid crystal; Materials Science

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

587-598

Volume

434

Citation

Shiyanovskii S V; Lavrentovich O D; Schneider T; Ishikawa T; Smalyukh I I; Woolverton C J; Niehaus G D; Doane K J, “Lyotropic chromonic liquid crystals for biological sensing applications,” NEOMED Bibliography Database, accessed September 28, 2021, https://neomed.omeka.net/items/show/7168.

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