Real-time microbe detection based on director distortions around growing immune complexes in lyotropic chromonic liquid crystals

Title

Real-time microbe detection based on director distortions around growing immune complexes in lyotropic chromonic liquid crystals

Creator

Shiyanovskii S V; Schneider T; Smalyukh I I; Ishikawa T; Niehaus G D; Doane K J; Woolverton C J; Lavrentovich O D

Publisher

Physical Review E

Date

2005
2005-02

Description

We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the particle's size. The effect allows us to propose a real-time microbial sensor based on a nontoxic lyotropic chromonic LC (LCLC) that detects and amplifies the presence of immune complexes. A cassette is filled with LCLC, antibody, and antigen-bearing particles. Small and isolated particles cause no macroscopic distortions of the LCLC. Upon antibody-antigen binding, the growing immune complexes distort the director and cause detectable optical transmittance between crossed polarizers.

Subject

cells; ligand-receptor binding; Physics

Format

Journal Article

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Rights

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Pages

4-4

Issue

2

Volume

71

Citation

Shiyanovskii S V; Schneider T; Smalyukh I I; Ishikawa T; Niehaus G D; Doane K J; Woolverton C J; Lavrentovich O D, “Real-time microbe detection based on director distortions around growing immune complexes in lyotropic chromonic liquid crystals,” NEOMED Bibliography Database, accessed September 16, 2021, https://neomed.omeka.net/items/show/7169.

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