Rodent models for ovarian cancer research

Rodent models for ovarian cancer research

Stakleff K D S; Von Gruenigen V E

International Journal of Gynecological Cancer

2003

2003-07

Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.

animal models; carcinoma cell-line; epithelial; gene-therapy; immunodeficient mice; luteinizing-hormone; lysophosphatidic acid; metastasis in-vivo; mouse models; neoplasms; nude-mice; Obstetrics & Gynecology; Oncology; ovarian-cancer; p53; review; tumor-associated antigens

Journal Article

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

405-412

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