Rodent models for ovarian cancer research

Title

Rodent models for ovarian cancer research

Creator

Stakleff K D S; Von Gruenigen V E

Publisher

International Journal of Gynecological Cancer

Date

2003
2003-07

Description

Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.

Subject

animal models; carcinoma cell-line; epithelial; gene-therapy; immunodeficient mice; luteinizing-hormone; lysophosphatidic acid; metastasis in-vivo; mouse models; neoplasms; nude-mice; Obstetrics & Gynecology; Oncology; ovarian-cancer; p53; review; tumor-associated antigens

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

405-412

Issue

4

Volume

13

Citation

Stakleff K D S; Von Gruenigen V E, “Rodent models for ovarian cancer research,” NEOMED Bibliography Database, accessed October 24, 2021, https://neomed.omeka.net/items/show/7219.

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