Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases

Title

Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases

Creator

Swanson H I; Wada T; Xie W; Renga B; Zampella A; Distrutti E; Fiorucci S; Kong B; Thomas A M; Guo G L; Narayanan R; Yepuru M; Dalton J T; Chiang J Y L

Publisher

Drug Metabolism and Disposition

Date

2013
2013-01

Description

This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 12 meeting in San Diego, CA. The presentations discussed the roles of a number of nuclear receptors in regulating glucose and lipid homeostasis, the pathophysiology of obesity-related disease states, and the promise associated with targeting their activities to treat these diseases. While many of these receptors (in particular, constitutive androstane receptor and pregnane X receptor) and their target enzymes have been thought of as regulators of drug and xenobiotic metabolism, this symposium highlighted the advances made in our understanding of the endogenous functions of these receptors. Similarly, as we gain a better understanding of the mechanisms underlying bile acid signaling pathways in the regulation of body weight and glucose homeostasis, we see the importance of using complementary approaches to elucidate this fascinating network of pathways. The observation that some receptors, like the farnesoid X receptor, can function in a tissue-specific manner via well defined mechanisms has important clinical implications, particularly in the treatment of liver diseases. Finally, the novel findings that agents that selectively activate estrogen receptor beta can effectively inhibit weight gain in a high-fat diet model of obesity identifies a new role for this member of the steroid superfamily. Taken together, the significant findings reported during this symposium illustrate the promise associated with targeting a number of nuclear receptors for the development of new therapies to treat obesity and other metabolic disorders.

Subject

bile-acid-homeostasis; carbohydrate-metabolism; constitutive androstane receptor; estrogen sulfotransferase; farnesoid X receptor; fatty liver-disease; glucose-homeostasis; heterodimer partner; insulin sensitivity; Pharmacology & Pharmacy; small; type-2 diabetes-mellitus

Format

Journal Article

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1-11

Issue

1

Volume

41

Citation

Swanson H I; Wada T; Xie W; Renga B; Zampella A; Distrutti E; Fiorucci S; Kong B; Thomas A M; Guo G L; Narayanan R; Yepuru M; Dalton J T; Chiang J Y L, “Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases,” NEOMED Bibliography Database, accessed July 27, 2021, https://neomed.omeka.net/items/show/7266.

Social Bookmarking