TREATMENT OF HOSPITALIZED-PATIENTS WITH COMPLICATED SKIN AND SKIN-STRUCTURE INFECTIONS - DOUBLE-BLIND, RANDOMIZED, MULTICENTER STUDY OF PIPERACILLIN-TAZOBACTAM VERSUS TICARCILLIN-CLAVULANATE

Title

TREATMENT OF HOSPITALIZED-PATIENTS WITH COMPLICATED SKIN AND SKIN-STRUCTURE INFECTIONS - DOUBLE-BLIND, RANDOMIZED, MULTICENTER STUDY OF PIPERACILLIN-TAZOBACTAM VERSUS TICARCILLIN-CLAVULANATE

Creator

Tan J S; Wishnow R M; Talan D A; Duncanson F P; Norden C W; Hanna C; Christou N; Bernstein J; Marsh P; Smith M; Sapico F; Murray G; Crockersmith L L; Segreti J; Gentry L; Cullison J; Sathe S; Low I; Lamothe F; Mersey J; Dall L; Laverdiere M; Mitchell J

Publisher

Antimicrobial Agents and Chemotherapy

Date

1993
1993-08

Description

We compared the efficacy and safety of two beta-lactam-beta-lactamase inhibitor combinations, namely, piperacillin-tazobactam and ticarcillin-clavulanate, in the treatment of complicated bacterial infections of skin that required hospitalization. The study was a randomized, double-blind, comparative trial involving 20 centers. The infections were classified as (i) cellulitis with drainage, (ii) cutaneous abscess, (iii) diabetic or ischemic foot infection, and (iv) infected wounds and ulcers with drainage. The clinical response rates were comparable for the two treatment regimens (61% of the patients were cured with piperacillin-tazobactam and ticarcillin-clavulanate and improvement was seen in 15 and 16% of patients treated with piperacillin-tazobactam and ticarcillin-clavulanate, respectively). Both regimens were found to be safe and well tolerated. These data support the use of piperacillin-tazobactam for initial empiric therapy of hospitalized patients with complicated skin and skin structure infections.

Subject

Microbiology; Pharmacology & Pharmacy

Format

Journal Article

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Rights

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Pages

1580-1586

Issue

8

Volume

37

Citation

Tan J S; Wishnow R M; Talan D A; Duncanson F P; Norden C W; Hanna C; Christou N; Bernstein J; Marsh P; Smith M; Sapico F; Murray G; Crockersmith L L; Segreti J; Gentry L; Cullison J; Sathe S; Low I; Lamothe F; Mersey J; Dall L; Laverdiere M; Mitchell J, “TREATMENT OF HOSPITALIZED-PATIENTS WITH COMPLICATED SKIN AND SKIN-STRUCTURE INFECTIONS - DOUBLE-BLIND, RANDOMIZED, MULTICENTER STUDY OF PIPERACILLIN-TAZOBACTAM VERSUS TICARCILLIN-CLAVULANATE,” NEOMED Bibliography Database, accessed April 12, 2024, https://neomed.omeka.net/items/show/7280.