Multifunctional drugs with different CNS targets for neuropsychiatric disorders

Title

Multifunctional drugs with different CNS targets for neuropsychiatric disorders

Creator

Van der Schyf C J; Geldenhuys W J; Youdim M B H

Publisher

Journal of Neurochemistry

Date

2006
2006-11

Description

The multiple disease etiologies that lead to neuropsychiatric disorders, such as Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis, Huntington disease, schizophrenia, depressive illness and stroke, offer significant challenges to drug discovery efforts aimed at preventing or even reversing the progression of these disorders. Transcriptomic tools and proteomic profiling have clearly indicated that such diseases are multifactorial in origin. Further, they are thought to be initiated by a cascade of molecular events that involve several neurotransmitter systems. In response to this complexity, a new paradigm has recently emerged that challenges the widely held assumption that 'silver bullet' agents are superior to 'dirty drugs' in therapeutic approaches aimed at the prevention or treatment of neuropsychiatric diseases. A similar pattern of drug development has occurred in strategies for the treatment of cancer, AIDS and cardiovascular diseases. In this review, we offer an overview of therapeutic strategies and novel investigative drugs discovered or developed in our own and other laboratories, that address multiple CNS etiological targets associated with an array of neuropsychiatric disorders.

Subject

alzheimers-disease; alzheimers-disease; amyotrophic lateral sclerosis; Biochemistry & Molecular Biology; depressive illness; designed multiple ligands; hetero-cage compounds; iron chelator; Lewy body disease; monoamine oxidase inhibitor; mptp-induced neurotoxicity; neurodegenerative diseases; Neurosciences & Neurology; nicotinic acetylcholine-receptors; nonsteroidal antiinflammatory drugs; parkinsons-disease; parkinsons-disease; schizophrenia

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1033-1048

Issue

4

Volume

99

Citation

Van der Schyf C J; Geldenhuys W J; Youdim M B H, “Multifunctional drugs with different CNS targets for neuropsychiatric disorders,” NEOMED Bibliography Database, accessed December 3, 2021, https://neomed.omeka.net/items/show/7386.

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