Assessment of Factors That Contribute to Decreased Quality of Life in Gynecologic Oncology Group Ovarian Cancer Trials

Title

Assessment of Factors That Contribute to Decreased Quality of Life in Gynecologic Oncology Group Ovarian Cancer Trials

Creator

Von Gruenigen V E; Huang H Q; Gil K M; Gibbons H E; Monk B J; Rose P G; Armstrong D K; Cella D; Wenzel L

Publisher

Cancer

Date

2009
2009-10

Description

BACKGROUND: The objective of this study was to assess which quality-of-life (QOL) line items on the Functional Assessment of Cancer Therapy-Ovarian (FACT-O) were associated with low QOL in women who were receiving chemotherapy for ovarian cancer. METHODS: Patients with stage III or IV ovarian cancer on Gynecologic Oncology Group Protocols 152 and 172 who underwent primary surgery followed by intravenous paclitaxel and cisplatin completed the FACT-O. The FACT scale includes the 4 domains of physical, functional, social, and emotional well being (PWB, FWB, SWB, EWB, respectively). Women who had overall FACT-O scores in the lowest quartile (01) were compared with women in the upper 3 quartiles (Q2-Q4). The proportions of women in each group that selected the 2 worst categories for each item were compared. The level of significance was set at P < .005. RESULTS: Before Cycle 4, 361 patients (86.4%) provided valid QOL assessments. For PWB, a significantly greater proportion of women in 01 versus Q2 through 04 selected the 2 worst categories of several physical symptoms (nausea, pain, feeling ill, and being bothered by the side effects of treatment). For FWB, significant differences included being able to work, being content with the quality of their life, and sleeping well. For EWB, there were significant differences in feeling nervous and worrying about dying. There were virtually no differences between groups in SWB. Low interest in sex was reported by 56% to 88% of all patients (Q1-Q4). CONCLUSIONS: A large proportion of women with FACT-O scores in the lowest quartile reported problems that potentially were amenable to clinical interventions, such as symptom management and psychosocial support. Cancer 2009;115:4857-64. (C) 2009 American Cancer Society.

Subject

carcinoma; chemotherapy; clinical interventions; cytoreduction; fatigue; functional assessment; Functional Assessment of Cancer Therapy; intervention; intraperitoneal; Oncology; psychosocial support; quality-of-life domains; survivors; symptom management

Identifier

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

4857-4864

Issue

20

Volume

115

Citation

Von Gruenigen V E; Huang H Q; Gil K M; Gibbons H E; Monk B J; Rose P G; Armstrong D K; Cella D; Wenzel L, “Assessment of Factors That Contribute to Decreased Quality of Life in Gynecologic Oncology Group Ovarian Cancer Trials,” NEOMED Bibliography Database, accessed May 18, 2021, https://neomed.omeka.net/items/show/7416.

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