Comparison of inotropic and chronotropic effects of vasoactive intestinal peptide in isolated dog atria

Title

Comparison of inotropic and chronotropic effects of vasoactive intestinal peptide in isolated dog atria

Creator

Wallick D W; Stuesse S L

Publisher

Journal of the Autonomic Nervous System

Date

1996
1996-12

Description

The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation, Atria were removed, maintained in a bath, and perfused with Tyrode's solution. Contractile force and atrial depolarization were measured, VIP (18.8-600 pmol) was injected into a cannulated sinoatrial nodal artery and dose response curves were obtained. The mean EC(50) was similar for the inotropic and the chronotropic responses (136 and 144 pmol, respectively). Time courses of the onset and of recovery from the responses were measured. Times for onset of VIP effects were similar but, once the effect was initiated, rate of development of the response and recovery time from the responses were dose dependent, The increases in atrial rate lasted two to four times longer than did the increases in contractile force. Recovery from the chronotropic and inotropic responses to VIP differ, suggesting that the intracellular responses are coupled differently to the receptors. The responses to VIP were compared to those of 100 pmol isoproterenol, another positive chronotropic and inotropic agent. Isoproterenol was a slightly more potent chronotropic and inotropic agent than VIP. Desensitization of the responses was determined. Repeated exposures to VIP decreased the chronotropic response but not the inotropic response to VIP. There was no significant decrease in responsiveness to isoproterenol.

Subject

adenylate-cyclase; anesthetized dogs; atrium; autonomic nervous system; cardiac; conscious dogs; contractile force; heart rate; heart rate; isoproterenol; neuropeptide; neuropeptides; Neurosciences & Neurology; parasympathetic; performance; polypeptide; receptor; receptors; Substance P; vip

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

257-263

Issue

3

Volume

61

Citation

Wallick D W; Stuesse S L, “Comparison of inotropic and chronotropic effects of vasoactive intestinal peptide in isolated dog atria,” NEOMED Bibliography Database, accessed September 21, 2021, https://neomed.omeka.net/items/show/7434.

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