Physicochemical characterization of liquid crystalline phases in model bile and lipid digestive mixtures: A H-2 NMR study

Title

Physicochemical characterization of liquid crystalline phases in model bile and lipid digestive mixtures: A H-2 NMR study

Creator

Westerman P W; Jacquet R; Quinn B; Rinaldi P L; Daunch W A; Sun Y

Publisher

Molecular Crystals and Liquid Crystals Science and Technology Section a-Molecular Crystals and Liquid Crystals

Date

1997
1997

Description

Phase properties of aqueous dispersions of model bile mixtures containing cholesterol, lecithin and bile salts and model mixed lipid digestive mixtures containing cholesterol, fatty acid, monoglyceride, lecithin and bile salts have been characterized by H-2 NMR. We have chemically incorporated a deuteriomethyl (CD3) group into one or two lipid components and utilized differences in motionally-averaged quadrupole splittings (Delta nu) and CD3 chemical shifts, to determine directly by peak-area integration, for a number of compositions on the phase diagram, the distribution of a H-2-labeled component between micellar, lamellar and solid phases, as well as the chemical compositions of these phases. Our data show that increasing cholesterol stabilizes lamellar phases whereas bile salts disrupt them and favor micelle formation.

Subject

Crystallography

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

287-292

Volume

299

Citation

Westerman P W; Jacquet R; Quinn B; Rinaldi P L; Daunch W A; Sun Y, “Physicochemical characterization of liquid crystalline phases in model bile and lipid digestive mixtures: A H-2 NMR study,” NEOMED Bibliography Database, accessed March 5, 2021, https://neomed.omeka.net/items/show/7576.

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