Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease?

Title

Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease?

Creator

Youdim M B H; Geldenhuys W J; Van der Schyf C J

Publisher

Parkinsonism & Related Disorders

Date

2007
2007

Description

Parkinson's disease (PD) is a severe neurodegenerative disorder, with no available drugs able to prevent the neuronal cell loss characteristic in brains of patients suffering from PD. Due to the complex cascade of molecular events involved in the etiology of PD, an innovative approach towards neuroprotection or neurorescue may entail the use of multifunctional pharmaceuticals that target an array of pathological pathways, each of which is believed to contribute to events that ultimately lead to neuronal cell death. Here we discuss examples of novel multifunctional ligands that may have potential as neuroprotective and neurorestorative therapeutics in PD. The compounds discussed originate from synthetic chemistry as well as from natural sources where various moieties, identified in research to possess neuroprotective and neurorestorative properties, have been introduced into the structures of several monomodal drugs, some of which are used in the clinic. (C) 2007 Elsevier B.V. All rights reserved.

Subject

A(2A) receptor antagonists; adenosine; alzheimers-disease; amyloid precursor protein; antagonist; bcl-2 family-members; designed multiple ligands; double-blind; dual mechanism; iron chelation; ladostigil; M30; mao-b; monoamine-oxidase-b; neurodegenerative diseases; Neurosciences & Neurology; nmda receptor; rasagiline; tea polyphenol (-)-epigallocatechin-3-gallate

Format

Journal Article

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

S281-S291

Volume

13

Citation

Youdim M B H; Geldenhuys W J; Van der Schyf C J, “Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease?,” NEOMED Bibliography Database, accessed March 4, 2021, https://neomed.omeka.net/items/show/7645.

Social Bookmarking