FARNESOID X RECEPTOR: ACTING THROUGH BILE ACIDS TO TREAT METABOLIC DISORDERS
Title
FARNESOID X RECEPTOR: ACTING THROUGH BILE ACIDS TO TREAT METABOLIC DISORDERS
Creator
Zhang Y
Publisher
Drugs of the Future
Date
2010
2010-08
Description
The famesoid X receptor (FXR) is a member of the nuclear receptor superfamily and plays an important role in maintaining bile acid, lipid and glucose homeostasis. Bile acids are endogenous ligands for FXR. However, bile acids may also activate pathways independent of FXR. The development of specific FXR agonists has provided important insights into the role of FXR in metabolism. Recent data have demonstrated that FXR is a therapeutic target for the treatment of certain metabolic disorders. This review will focus on recent advances in the role of FXR in metabolic disease.
Subject
fatty liver-disease; foam-cell formation; growth-factor receptor; heterodimer partner; insulin-resistance; nonalcoholic steatohepatitis; orphan nuclear receptor; Pharmacology & Pharmacy; primary rat hepatocytes; protein-kinase-c; regulatory cascade; small
Identifier
Format
Journal Article
URL Address
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Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
635-641
Issue
8
Volume
35
Citation
Zhang Y, “FARNESOID X RECEPTOR: ACTING THROUGH BILE ACIDS TO TREAT METABOLIC DISORDERS,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/7652.