FARNESOID X RECEPTOR: ACTING THROUGH BILE ACIDS TO TREAT METABOLIC DISORDERS

Title

FARNESOID X RECEPTOR: ACTING THROUGH BILE ACIDS TO TREAT METABOLIC DISORDERS

Creator

Zhang Y

Publisher

Drugs of the Future

Date

2010
2010-08

Description

The famesoid X receptor (FXR) is a member of the nuclear receptor superfamily and plays an important role in maintaining bile acid, lipid and glucose homeostasis. Bile acids are endogenous ligands for FXR. However, bile acids may also activate pathways independent of FXR. The development of specific FXR agonists has provided important insights into the role of FXR in metabolism. Recent data have demonstrated that FXR is a therapeutic target for the treatment of certain metabolic disorders. This review will focus on recent advances in the role of FXR in metabolic disease.

Subject

fatty liver-disease; foam-cell formation; growth-factor receptor; heterodimer partner; insulin-resistance; nonalcoholic steatohepatitis; orphan nuclear receptor; Pharmacology & Pharmacy; primary rat hepatocytes; protein-kinase-c; regulatory cascade; small

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

635-641

Issue

8

Volume

35

Citation

Zhang Y, “FARNESOID X RECEPTOR: ACTING THROUGH BILE ACIDS TO TREAT METABOLIC DISORDERS,” NEOMED Bibliography Database, accessed May 6, 2021, https://neomed.omeka.net/items/show/7652.

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