Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter

Title

Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter

Creator

Zheng G R; Zhang Z F; Lockman P R; Geldenhuys W J; Allen D D; Dwoskin L P; Crooks P A

Publisher

Bioorganic & Medicinal Chemistry Letters

Date

2010
2010-06

Description

A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The preliminary structure-activity relationships obtained from this study suggest that incorporating a linear, conformationally restricted linker into the molecule improves affinity for the BBB-ChT. (C) 2010 Elsevier Ltd. All rights reserved.

Subject

12-diyl-bis-3-picolinium dibromide; analogs; Bis-quaternary ammonium salts; Blood-brain barrier; Chemistry; Choline transporter; evoked dopamine release; extracellular dopamine; hyperactivity; mediated transport; n; n'-dodecane-1; nicotinic-receptor antagonist; nucleus-accumbens; Pharmacology & Pharmacy; rat; tobacco dependence; vector

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

3208-3210

Issue

11

Volume

20

Citation

Zheng G R; Zhang Z F; Lockman P R; Geldenhuys W J; Allen D D; Dwoskin L P; Crooks P A, “Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter,” NEOMED Bibliography Database, accessed May 8, 2021, https://neomed.omeka.net/items/show/7655.

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