Prostate cancer and other xenografts from cells in peripheral blood of patients

Prostate cancer and other xenografts from cells in peripheral blood of patients

Pretlow T G; Schwartz S; Giaconia J M; Wright A L; Grimm H A; Edgehouse N L; Murphy J R; Markowitz S D; Jamison J M; Summers J L; Hamlin C R; MacLennan G T; Resnick M I; Pretlow T P; Connell C F

Cancer Research

2000

2000-08

Good models for the investigation of human prostate cancer are few. Cells from approximately 9.2-21 ml of peripheral blood from patients with metastatic prostate cancer or metastatic colon cancer were injected s.c. into nude mice. Prostate cancer from 2 of 11 patients and colon cancer from 1 of 3 patients were found to be growing as metastases in the lungs of the nude mice. To our knowledge, this is the first report of the formation of xenografts from carcinoma cells taken directly from the peripheral blood of patients. Expanding circulating cancer cells with this approach may have important translational applications including: (a) development of models of human cancers; and (b) sampling of cancers from specific patients for novel molecular and therapeutic approaches.

carcinoma; cwr22; matrigel; membrane; mice; Oncology; tumor-growth

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Journal Article

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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

4033-4036

15

60