Serum Folate: A Pharmacodynamic Biomarker of Intracellular Nitrosylcobalamin Activity Following Intravenous Administration in Dogs
Title
Serum Folate: A Pharmacodynamic Biomarker of Intracellular Nitrosylcobalamin Activity Following Intravenous Administration in Dogs
Creator
Sysel A M; Horne W I; Steiner J M; Suchodolski J S; Bauer J A
Publisher
Anticancer Research
Date
2012
2012-10
Description
Background/Aim: Cobalamin and folate are interdependent co-factors of the methionine synthase pathway. This study evaluated the effect of intravenously-administered nitrosylcobalamin (NO-Cbl), a vitamin B12 analog, on serum folate concentrations in healthy dogs. Materials and Methods: Four dogs received a 10-mg/kg, 20-mg/kg and 40-mg/kg intravenous bolus dose of NO-Cbl, with a 14-day washout period between doses. Blood samples were collected at baseline and post-dosing, and serum cobalamin and folate concentrations were measured. Results: For each dose, serum cobalamin concentrations were inversely correlated with serum folate concentrations. Spearman rank correlation coefficient values were -0.976 (10 mg/kg, p<0.0096), and -1.0 (20 mg/kg, p<0.008; 40 mg/kg, p<0.0046). Conclusion: Cellular uptake of NO-Cbl, following intravenous administration exerted a biological effect on folate similar to that previously described for other vitamin B12 analogs. Serum folate concentration may serve as a pharmacodynamic biomarker of intracellular nitrosylcobalamin activity following intravenous administration.
Subject
apo2l/trail; biomarker; cells; cobalamin; disease; dogs; Folate; homocysteine; methylmalonic acid; nitric-oxide; Nitrosylcobalamin; Oncology; pharmacokinetics; supplementation; suppression; vitamin B-12; vitamin B-12
Identifier
n/a
Format
Journal Article
URL Address
n/a
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Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4307-4312
Issue
10
Volume
32
Citation
Sysel A M; Horne W I; Steiner J M; Suchodolski J S; Bauer J A, “Serum Folate: A Pharmacodynamic Biomarker of Intracellular Nitrosylcobalamin Activity Following Intravenous Administration in Dogs,” NEOMED Bibliography Database, accessed June 7, 2023, https://neomed.omeka.net/items/show/8137.