Synthesis of 3 beta-(4- I-125 Iodophenyl)tropane-2 beta-pyrrolidine carboxamide ( I-125 RTI-229)

Synthesis of 3 beta-(4- I-125 Iodophenyl)tropane-2 beta-pyrrolidine carboxamide ( I-125 RTI-229)

Zhong D S; Kotian P; Wyrick C D; Seltzman H H; Kepler J A; Boja J W; Kuhar M J; Carroll F I

Journal of Labelled Compounds & Radiopharmaceuticals

1999

1999-03

A WIN 35,055-2 analog, 3 beta-(4-iodophenyl)tropane-2 beta-pyrrolidine carboxamide (RTI-229), has been radiolabelled with iodine-125 by radioiododestannylation of the corresponding trimethyltin derivative using carrier-free sodium iodide-125 as the isotope source. Purification by reversed-phase HPLC gives [I-125]RTI-229 in good yield (89.4%) with high radiochemical purity (>99%) and high specific activity (2125 mCi/mu mol, 78.6 GBq/mu mol, based on the specific activity of the (NaI)-I-125 used).

acid isopropyl ester; analogs; Biochemistry & Molecular Biology; brain; Chemistry; chloramine-T; cocaine; dopamine transporter; high-affinity; iodine-125 labelling; iododestannylation; ligand; nonhuman primates; Pharmacology & Pharmacy; radioiodination; RTI-229

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Journal Article

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