AGS proteins: receptor-independent activators of G-protein signaling
Title
AGS proteins: receptor-independent activators of G-protein signaling
Creator
Blumer J B; Cismowski M J; Sato M; Lanier S M
Publisher
Trends in Pharmacological Sciences
Date
2005
2005-09
Description
The identification of AGS proteins as receptor-independent activators of G-protein signaling reveals unexpected mechanisms for the regulation of heterotrimeric G-protein activation and has opened up new areas of research related to the role of G proteins as signal transducers. In addition to their obvious interest associated with G-protein-coupled receptor signaling, AGS proteins might provide alternative binding partners for G-protein subunits that enable them to serve unexpected functions related to cell division, differentiation and organelle structure that might operate independently of a GPCR. Thus, these proteins and the concepts advanced with their discovery highlight the diversity associated with G-protein signaling and present new avenues for the development of therapeutics that target G-protein signaling.
Subject
Pharmacology & Pharmacy; protein; heterotrimeric g-proteins; C. elegans; accessory proteins; asymmetric cell-division; dissociation inhibitor activity; g-alpha subunits; goloco motif; nucleotide exchange factor; ras-related; regulatory motifs
Identifier
Format
Journal Article or Conference Abstract Publication
URL Address
Search for Full-text
Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
470-476
Issue
9
Volume
26
Citation
Blumer J B; Cismowski M J; Sato M; Lanier S M, “AGS proteins: receptor-independent activators of G-protein signaling,” NEOMED Bibliography Database, accessed November 10, 2024, https://neomed.omeka.net/items/show/8647.