AGS proteins: receptor-independent activators of G-protein signaling

Title

AGS proteins: receptor-independent activators of G-protein signaling

Creator

Blumer J B; Cismowski M J; Sato M; Lanier S M

Publisher

Trends in Pharmacological Sciences

Date

2005
2005-09

Description

The identification of AGS proteins as receptor-independent activators of G-protein signaling reveals unexpected mechanisms for the regulation of heterotrimeric G-protein activation and has opened up new areas of research related to the role of G proteins as signal transducers. In addition to their obvious interest associated with G-protein-coupled receptor signaling, AGS proteins might provide alternative binding partners for G-protein subunits that enable them to serve unexpected functions related to cell division, differentiation and organelle structure that might operate independently of a GPCR. Thus, these proteins and the concepts advanced with their discovery highlight the diversity associated with G-protein signaling and present new avenues for the development of therapeutics that target G-protein signaling.

Subject

Pharmacology & Pharmacy; protein; heterotrimeric g-proteins; C. elegans; accessory proteins; asymmetric cell-division; dissociation inhibitor activity; g-alpha subunits; goloco motif; nucleotide exchange factor; ras-related; regulatory motifs

Format

Journal Article or Conference Abstract Publication

Search for Full-text

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

470-476

Issue

9

Volume

26

Citation

Blumer J B; Cismowski M J; Sato M; Lanier S M, “AGS proteins: receptor-independent activators of G-protein signaling,” NEOMED Bibliography Database, accessed December 6, 2021, https://neomed.omeka.net/items/show/8647.

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