Impaired function of coronary BKCa channels in metabolic syndrome

Title

Impaired function of coronary BKCa channels in metabolic syndrome

Creator

Borbouse L; Dick G M; Asano S; Bender S B; Dincer U D; Payne G A; Neeb Z P; Bratz I N; Sturek M; Tune J D

Publisher

American Journal of Physiology-Heart and Circulatory Physiology

Date

2009
2009-11

Description

Borbouse L, Dick GM, Asano S, Bender SB, Dincer UD, Payne GA, Neeb ZP, Bratz IN, Sturek M, Tune JD. Impaired function of coronary BKCa channels in metabolic syndrome. Am J Physiol Heart Circ Physiol 297: H1629-H1637, 2009. First published September 11, 2009; doi:10.1152/ajpheart.00466.2009.-The role of large-conductance Ca2+-activated K+ (BKCa) channels in regulation of coronary microvascular function is widely appreciated, but molecular and functional changes underlying the deleterious influence of metabolic syndrome (MetS) have not been determined. Male Ossabaw miniature swine consumed for 3-6 mo a normal diet (11% kcal from fat) or an excess-calorie atherogenic diet that induces MetS (45% kcal from fat, 2% cholesterol, 20% kcal from fructose). MetS significantly impaired coronary vasodilation to the BKCa opener NS-1619 in vivo (30-100 mu g) and reduced the contribution of these channels to adenosine-induced microvascular vasodilation in vitro (1-100 mu M). MetS reduced whole cell penitrem A (1 mu M)-sensitive K+ current and NS-1619-activated (10 mu M) current in isolated coronary vascular smooth muscle cells. MetS increased the concentration of free intracellular Ca2+ and augmented coronary vasoconstriction to the L-type Ca2+ channel agonist BAY K 8644 (10 pM-10 nM). BKCa channel alpha and beta(1) protein expression was increased in coronary arteries from MetS swine. Coronary vascular dysfunction in MetS is related to impaired BKCa channel function and is accompanied by significant increases in L-type Ca2+ channel-mediated coronary vasoconstriction.

Subject

obesity; Physiology; Cardiovascular System & Cardiology; channels; smooth-muscle-cells; circulation; cardiovascular-disease; Ion channels; beta-1 subunit; activated potassium; arteriolar dilation; blood flow; ca2+-activated k+ channels; currents; diabetic fatty rats; induced relaxation; large-conductance; outward

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

H1629-H1637

Issue

5

Volume

297

Citation

Borbouse L; Dick G M; Asano S; Bender S B; Dincer U D; Payne G A; Neeb Z P; Bratz I N; Sturek M; Tune J D, “Impaired function of coronary BKCa channels in metabolic syndrome,” NEOMED Bibliography Database, accessed October 22, 2021, https://neomed.omeka.net/items/show/8668.

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