Complications of anesthesia for children with malignant infantile osteopetrosis before and after hematopoietic stem cell transplantation

Title

Complications of anesthesia for children with malignant infantile osteopetrosis before and after hematopoietic stem cell transplantation

Creator

Burgoyne L L; Kaur A; Billups C A; Parish M E; Kaddoum R N; Bikhazi G B; Pereiras L A

Publisher

Pediatric Anesthesia

Date

2010
2010-11

Description

P>Objectives and aims: The primary aim was to determine the frequency of anesthetic-related complications for patients with malignant infantile osteopetrosis (MIOP) before and after hematopoietic stem cell transplant (HSCT). The secondary aims were to describe the types of complications that occurred, to determine whether the risk of anesthetic complications was altered by HSCT, and to determine the frequency of difficult intubation. Background: Patients with MIOP undergo HSCT, often in infancy, and anesthesia is frequently required for investigations and procedures associated with transplantation. Although MIOP has adverse implications for anesthetic management, the literature describing the anesthetic management of MIOP patients is limited. Methods: A retrospective review of medical and anesthetic records was undertaken between November 2000 and March 2008. Results: Eleven patients underwent 127 anesthetics. The overall complication rate was 11%. Before HSCT, there were 12 complications in 62 anesthetics (19.3%). After HSCT, there were two complications in 65 anesthetics (3.2%). This difference was not statistically significant. All of the complications were airway or respiratory events. Of the 26 intubations associated with anesthesia, 23 (88.5%) were easy, 1 (3.8%) was moderately difficult, and 2 (7.7%) were difficult. Conclusion: Complications associated with anesthesia for infants and children with MIOP having HSCT are fairly common and are usually airway or respiratory related. Difficult endotracheal intubation is also common.

Subject

diagnosis; Pediatrics; intubation; osteopetrosis; management; morbidity; Anesthesiology; complication; autosomal recessive osteopetrosis; anaesthesia

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1046-1051

Issue

11

Volume

20

Citation

Burgoyne L L; Kaur A; Billups C A; Parish M E; Kaddoum R N; Bikhazi G B; Pereiras L A, “Complications of anesthesia for children with malignant infantile osteopetrosis before and after hematopoietic stem cell transplantation,” NEOMED Bibliography Database, accessed December 1, 2021, https://neomed.omeka.net/items/show/8764.

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