ULTRASTRUCTURAL CHARACTERISTICS OF A CELL-LINE DERIVED FROM A MELANOTIC NEUROECTODERMAL TUMOR OF INFANCY
Title
ULTRASTRUCTURAL CHARACTERISTICS OF A CELL-LINE DERIVED FROM A MELANOTIC NEUROECTODERMAL TUMOR OF INFANCY
Creator
Claman L J; Stetson D; Steinberg B; Shuler C F
Publisher
Journal of Oral Pathology & Medicine
Date
1991
1991-05
Description
Thin section and freeze-fracture transmission electron microscopy were used to examine and identify the cytoplasmic and membrane structures in a cell line derived from a melanotic neuroectodermal tumor of infancy (MNTI). The cultured cells had a uniform appearance after 70 population doublings characterized by long dendritic processes and evidence of melanin production. The cytoplasm contained numerous melanosomes in various stages of development, vesiculated rough endoplasmic reticulum, microfilaments and uncoated as well as coated vesicles. The membrane specializations included caveoli, coated pits, gap junctions, microfilaments, desmosome-like structures and lamellipodia. The ultrastructural appearance of the cultured MNTI cells was similar to features previously seen in electron micrographs of MNTI tumor specimens. However, correlated freeze-fracture and thin section micrographs permitted further identification of structures previously described. The MNTI cell line represents one of the cell types of the tumor and provides an opportunity for further study of the pathogenesis of this rare tumor.
Subject
Pathology; cell line; Dentistry; Oral Surgery & Medicine; freeze-fracture; melanotic neuroectodermal tumor of infancy; transmission electron microscopy
Identifier
Format
Journal Article or Conference Abstract Publication
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Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
245-249
Issue
5
Volume
20
Citation
Claman L J; Stetson D; Steinberg B; Shuler C F, “ULTRASTRUCTURAL CHARACTERISTICS OF A CELL-LINE DERIVED FROM A MELANOTIC NEUROECTODERMAL TUMOR OF INFANCY,” NEOMED Bibliography Database, accessed April 25, 2024, https://neomed.omeka.net/items/show/8948.