Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel

Title

Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel

Creator

Deenadayalu V U P; White R E; Stallone J N; Gao X M; Garcia A J

Publisher

American Journal of Physiology-Heart and Circulatory Physiology

Date

2001
2001-10

Description

Cardiovascular diseases are often considered to be a predominantly male health problem, and it has been suggested that testosterone exerts deleterious effects on cardiovascular function; however, few experimental studies support this suggestion. Moreover, the cellular and molecular mechanism(s) underlying vascular responses to testosterone is unknown. The present study has investigated the acute effects of testosterone on porcine coronary artery smooth muscle at the tissue and cellular levels. Contractile studies demonstrated that testosterone or dihydrotestosterone (a nonaromatizable metabolite) relaxed these arteries by an endothelium-independent mechanism involving potassium efflux. Direct evidence from patch-clamp studies confirmed that testosterone opened K+ channels in single coronary myocytes, and further analysis identified this protein as the large-conductance, calcium- and voltage-activated potassium (BKCa) channel. Moreover, inhibiting BKCa channel activity significantly attenuated testosterone-induced coronary relaxation. These findings indicate that testosterone relaxes porcine coronary arteries predominantly by opening BKCa channels in coronary myocytes, and this response may be associated with accumulation of cGMP. This novel mechanism may provide a better understanding of testosterone-induced vasorelaxation reported in recent experimental and early clinical studies.

Subject

rat; vasodilation; ion channel; Physiology; Cardiovascular System & Cardiology; disease; smooth-muscle-cells; aorta; men; Vascular; hormones; androgen; steroid

Identifier

n/a

Format

Journal Article or Conference Abstract Publication

URL Address

n/a

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

H1720-H1727

Issue

4

Volume

281

Citation

Deenadayalu V U P; White R E; Stallone J N; Gao X M; Garcia A J, “Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel,” NEOMED Bibliography Database, accessed June 16, 2021, https://neomed.omeka.net/items/show/9036.

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