Interactive effects of tamoxifen and oestrogen upon the nigrostriatal dopaminergic system: Long-term treatments

Interactive effects of tamoxifen and oestrogen upon the nigrostriatal dopaminergic system: Long-term treatments

McDermott J L; Anderson L I; Dluzen D E

Journal of Neuroendocrinology

1999

1999-10

In the present report adult female rats were ovariectomized (OVX) and assigned to one of four treatment conditions. Treatments consisted of administering pellets containing 17 beta-oestradiol (E), tamoxifen (TMX), a combination of TMX and E or no further treatment (OVX), Animals received these treatments immediately following OVX and were maintained in these conditions for a 40-day period. Subsequently, the corpus striatum (CS) was dissected from each animal and prepared for determinations of basal and amphetamine stimulated DA output using in-vitro superfusion. No statistically significant differences among the four treatment groups were obtained for basal dopamine output. The highest levels of amphetamine-stimulated dopamine responses were obtained from E treated rats. These values were significantly greater than that obtained from OVX rats and rats treated with a combination of TMX + E. The significance of these findings is that they indicate both a non-traditional central nervous system site and mechanism of action through which tamoxifen-oestrogen interactions can function. Such data may have important implications for administration of tamoxifen to premenopausal women as this anti-oestrogen may compromise nigrostriatal dopaminergic function under conditions where oestrogenic modulation is present.

receptors; Neurosciences & Neurology; Endocrinology & Metabolism; estrogen; binding; catecholamines; brain; striatum; time; amphetamine; estradiol; antiestrogens; ovarian steroids; sexual-behavior; anti-oestrogens

n/a

Journal Article or Conference Abstract Publication

n/a

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

801-803

10

11