TREATMENT OF HIRSUTISM WITH A GONADOTROPIN-RELEASING-HORMONE AGONIST AND ESTROGEN REPLACEMENT THERAPY

Title

TREATMENT OF HIRSUTISM WITH A GONADOTROPIN-RELEASING-HORMONE AGONIST AND ESTROGEN REPLACEMENT THERAPY

Creator

Morcos R N; Abdulmalak M E; Shikora E

Publisher

Fertility and Sterility

Date

1994
1994-03

Description

Objective: To determine the efficacy of treatment of significant hirsutism with a GnRH agonist (GnRH-a) and estrogen and progestin replacement therapy. Design: Clinical series. Setting: Ambulatory gynecology clinic in a community hospital. Patients: Ten women with significant hirsutism caused by polycystic ovarian disease. Interventions: The patients were treated with leuprolide acetate 20 mu g/kg per day in combination with E(2) (2 mg) and medroxyprogesterone acetate (5 mg) for 6 months. Main Outcome Measure: Hirsutism scores and hair growth rates determined before and upon completion of treatment protocol. Results: Hirsutism scores and hair growth rates significantly decreased by 23% and 26%, respectively. The duration of hirsutism was the only significant covariate for hirsutism scores and hair growth rates. Only two patients had minimal, irregular bleeding that was corrected by increasing the estrogen dose. Conclusion: The combination of a GnRH-a and estrogen replacement therapy was an effective and well-tolerated treatment in a small group of women with significant hirsutism caused by PCOD.

Subject

Reproductive Biology; women; Obstetrics & Gynecology; suppression; spironolactone; estrogen replacement therapy; gnrh-a; hirsutism; leuprolide; nafarelin; polycystic ovarian disease

Identifier

n/a

Format

Journal Article or Conference Abstract Publication

URL Address

n/a

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

427-431

Issue

3

Volume

61

Citation

Morcos R N; Abdulmalak M E; Shikora E, “TREATMENT OF HIRSUTISM WITH A GONADOTROPIN-RELEASING-HORMONE AGONIST AND ESTROGEN REPLACEMENT THERAPY,” NEOMED Bibliography Database, accessed May 18, 2021, https://neomed.omeka.net/items/show/9172.

Social Bookmarking