TREATMENT OF HIRSUTISM WITH A GONADOTROPIN-RELEASING-HORMONE AGONIST AND ESTROGEN REPLACEMENT THERAPY

TREATMENT OF HIRSUTISM WITH A GONADOTROPIN-RELEASING-HORMONE AGONIST AND ESTROGEN REPLACEMENT THERAPY

Morcos R N; Abdulmalak M E; Shikora E

Fertility and Sterility

1994

1994-03

Objective: To determine the efficacy of treatment of significant hirsutism with a GnRH agonist (GnRH-a) and estrogen and progestin replacement therapy. Design: Clinical series. Setting: Ambulatory gynecology clinic in a community hospital. Patients: Ten women with significant hirsutism caused by polycystic ovarian disease. Interventions: The patients were treated with leuprolide acetate 20 mu g/kg per day in combination with E(2) (2 mg) and medroxyprogesterone acetate (5 mg) for 6 months. Main Outcome Measure: Hirsutism scores and hair growth rates determined before and upon completion of treatment protocol. Results: Hirsutism scores and hair growth rates significantly decreased by 23% and 26%, respectively. The duration of hirsutism was the only significant covariate for hirsutism scores and hair growth rates. Only two patients had minimal, irregular bleeding that was corrected by increasing the estrogen dose. Conclusion: The combination of a GnRH-a and estrogen replacement therapy was an effective and well-tolerated treatment in a small group of women with significant hirsutism caused by PCOD.

Reproductive Biology; women; Obstetrics & Gynecology; suppression; spironolactone; estrogen replacement therapy; gnrh-a; hirsutism; leuprolide; nafarelin; polycystic ovarian disease

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Journal Article or Conference Abstract Publication

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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

427-431

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