In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have…
Introduction The United States ranks 27th among nations worldwide for infant mortality with a rate of 6.1 deaths per 1,000 live births. The majority of perinatal morbidity and mortality is related to preterm birth, defined as delivery prior to 37…
BACKGROUND: Subjective tinnitus is a hearing disorder in which a person perceives sound when no external sound is present. It can be acute or chronic. Because our current understanding of its pathology is incomplete, no effective cures have yet been…
We report a case of biopsy-proven orbital lymphangioma with contiguous spread intracranially in a 14-year-old boy. The patient had a history of congenital orbital lymphangioma and hydrocephalus. Multiple functional and cosmetic periorbital surgeries…
The eyelids, essential to protecting and cleansing the eye, are a common site for a range of disorders affecting older adults. Some of the e are benign and some serious, with the most clinically important being suspicious lid lesions that may harbor…
The eyelids provide a vital function in protecting and cleansing the eye but are also the source of numerous disorders and complaints in your older patients. Clinically, the most important of these problems are suspicious lid lesions that may harbor…
The superior colliculus is a paired structure in the rostral midbrain that is involved in incorporating environmental stimuli and coordinating gaze shifts involving both eye and head movements. It is known as the optic tectum in other vertebrates and…
OBJECTIVE: To evaluate the outcome of recalcitrant deep pelvic infection that required a hemipelvic amputation. STUDY DESIGN: Retrospective cohort. SETTING: Tertiary referral centre; Level I trauma. PATIENTS: There were 20 patients with an infection…
The external fixator has been in use for more than a century. Wutzer (1789-1863) used pins and an interconnecting rod-and-clamp system. Parkhill (1897) and Lambotte (1900) used devices that were unilateral with four pins and a bar-clamp system. By…
Background: There are numerous autograft alternatives promoted. Although most have laboratory or animal data, few have evaluations of clinical performance. We performed an evaluation of a new calcium sulfate-demineralized bone matrix/Allomatrix in…
Background: We evaluated a percutaneous, computed tomographic, stabilization from S1 to S2, for chronic painful sacroiliac disease. Our hypothesis was that this technique carries low morbidity, and may provide substantial relief of recalcitrant…
Objectives: We evaluated the economic aspects of an orthopaedic trauma section at a regional Level 1, semi-academic community hospital. This study analyzes the economics of a dedicated hospital-based orthopaedic trauma program. Methods: Institutional…
Vaccines have eliminated diseases such as syphilis and malaria from many regions of the world and because they are administered a few times at most they are more cost-effective than many drugs that treat the same conditions. However vaccines are not…
The mouse model of collagen induced arthritis (CIA) effectively mimics human disease and thus is useful for testing and development of rheumatoid arthritis (RA) therapies. We developed a Ligand Epitope Antigen Presentation System (LEAPS) peptide…
The Ligand Epitope Antigen Presentation System ( L. E. A. P. S. TM) approach to vaccine development utilizes immune peptides to promote the immunogenicity and influence the type of immune response generated towards epitopes in peptides which may be…
We previously analyzed human prostate tissue containing stroma near to tumor and from cancer-negative tissues of volunteers. Over 100 candidate gene expression differences were identified and used to develop a classifier that could detect nearby…
Aberrant liver sirtuin 1 (SIRT1), a mammalian NAD+-dependent protein deacetylase, is implicated in the pathogenesis of alcoholic liver disease. However, the role of intestinal SIRT1 in alcoholic liver disease is presently unknown. This study…
Lipin‐1 is a Mg2+‐dependent phosphatidic acid phosphohydrolase involved in the generation of diacylglycerol during synthesis of phospholipids and triglycerides. Ethanol‐mediated inhibitory effects on adipose‐specific lipin‐1 expression were…
UNLABELLED: Accumulating evidence over the last 40years suggests that silicate from dietary as well as silicate-containing biomaterials is beneficial to bone formation. However, the exact biological role(s) of silicate on bone cells are still unclear…
Gingival hyperplasia is a well-known complication of therapy with cyclosporine, calcium channel blockers, and phenytoin, It is characterized by the presence of inflammation and a marked fibrotic response. The mechanism of this adverse reaction is…
We have previously found that for acetaminophen kinetic differences exist between the hepatic microsomal catalyzed protein binding and cysteine conjugation. We have also observed that the protein binding of acetaminophen is only to intralumenal…
Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial…
Purpose: To investigate the association of overall and disease-specific survival with the five standard treatment modalities for prostate cancer (CaP): radical prostatectomy (RP), brachytherapy (BT), external beam radiotherapy, androgen deprivation…
A WIN 35,055-2 analog, 3 beta-(4-iodophenyl)tropane-2 beta-pyrrolidine carboxamide (RTI-229), has been radiolabelled with iodine-125 by radioiododestannylation of the corresponding trimethyltin derivative using carrier-free sodium iodide-125 as the…
Heat shock protein 27 (Hsp27) is a chaperone protein, and its expression is increased in response to various stress stimuli including anticancer chemotherapy, which allows the cells to survive and causes drug resistance. We previously identified lead…
A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The…
