Approaching A Consensus Cognitive Battery For Clinical Trials In Schizophrenia: The Nimh-matrics Conference To Select Cognitive Domains And Test Criteria

Title

Approaching A Consensus Cognitive Battery For Clinical Trials In Schizophrenia: The Nimh-matrics Conference To Select Cognitive Domains And Test Criteria

Creator

Green M F; Nuechterlein K H; Gold J M; Barch D M; Cohen J; Essock S; Fenton W S; Frese F; Goldberg T E; Heaton R K; Keefe R S E; Kern R S; Kraemer H; Stover E; Weinberger D R; Zalcman S; Marder S R

Publisher

Biological Psychiatry

Date

2004
2004-09

Description

To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) establisbed the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference . The goals of the meeting were to 1) the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria, for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literatum and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory. Reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizopbrenia.

Subject

cognition; cognitive assessment; cognitive enhancement; impairment; memory; neural basis; neurocognition; neurocognitive deficits; neuroleptic-naive; neuropsychological function; Neurosciences & Neurology; performance; Psychiatry; psychopharmacology; risperidone; schizophrenia; siblings; thought-disorder

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

301-307

Issue

5

Volume

56

Citation

Green M F; Nuechterlein K H; Gold J M; Barch D M; Cohen J; Essock S; Fenton W S; Frese F; Goldberg T E; Heaton R K; Keefe R S E; Kern R S; Kraemer H; Stover E; Weinberger D R; Zalcman S; Marder S R, “Approaching A Consensus Cognitive Battery For Clinical Trials In Schizophrenia: The Nimh-matrics Conference To Select Cognitive Domains And Test Criteria,” NEOMED Bibliography Database, accessed September 18, 2021, https://neomed.omeka.net/items/show/10009.

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