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Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity.

Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor…

Brain morphological abnormalities in children with cyclin-dependent kinase-like 5 deficiency disorder.

BACKGROUND: To quantitatively evaluate the brain MRI morphological abnormalities in patients with cyclin-dependent kinase-like 5 deficiency disorder…

Esophageal Obstruction and Death in a Nonverbal Patient.

BACKGROUND: There are more than 100,000 cases of esophageal foreign body in the United States each year. Most cases resolve spontaneously; however,…

Fatal self-injury in the United States, 1999-2018: Unmasking a national mental health crisis.

BACKGROUND: Suicides by any method, plus 'nonsuicide' fatalities from drug self-intoxication (estimated from selected forensically undetermined and …

Anatomy, Head and Neck, Digastric Muscle.

The digastrics are a pair of muscles individually made up of two distinct muscle bellies: the anterior and posterior digastrics. They derive…

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention,…

miR-467 regulates inflammation and blood insulin and glucose

Obesity is associated with inflammation and insulin resistance (IR), but the regulation of insulin sensitivity (IS) and connections between IS and…