Bone remodeling in the longest living rodent, the naked mole-rat: Interelement variation and the effects of reproduction.

Bone remodeling in the longest living rodent, the naked mole-rat: Interelement variation and the effects of reproduction.

Montoya-Sanhueza G;Bennett NC;Oosthuizen MK;Dengler-Crish CM;Chinsamy A

Journal Of Anatomy

2021

2021-02-07

Over 268 undecalcified thin cross-sections from the midshaft of humerus, ulna, femur and tibia were analyzed with confocal fluorescence and polarized light microscopy. Fluorochrome analysis revealed low osteogenesis, scarce bone resorption and infrequent formation of secondary osteons (Haversian systems) (i.e., slow bone turnover), thus most likely reflecting the low metabolic rates of this species.

The pattern of bone remodeling of one of the most peculiar mammals in the world, the naked mole-rat (NMR), was assessed. NMRs are known for their long lifespans among rodents and for having low metabolic rates. We assessed long-term in vivo bone labeling of subordinate individuals, as well as the patterns of bone resorption and bone remodeling in a large sample including reproductive and non-reproductive individuals (n = 70).

Journal Article

81-100

1

239

NEOMED College of Medicine

Department of Pharmaceutical Sciences

Jan to Aug list 2021