Bone remodeling in the longest living rodent, the naked mole-rat: Interelement variation and the effects of reproduction.
Title
Bone remodeling in the longest living rodent, the naked mole-rat: Interelement variation and the effects of reproduction.
Creator
Montoya-Sanhueza G;Bennett NC;Oosthuizen MK;Dengler-Crish CM;Chinsamy A
Publisher
Journal Of Anatomy
Date
2021
2021-02-07
Description
Over 268 undecalcified thin cross-sections from the midshaft of humerus, ulna, femur and tibia were analyzed with confocal fluorescence and polarized light microscopy. Fluorochrome analysis revealed low osteogenesis, scarce bone resorption and infrequent formation of secondary osteons (Haversian systems) (i.e., slow bone turnover), thus most likely reflecting the low metabolic rates of this species.
Subject
The pattern of bone remodeling of one of the most peculiar mammals in the world, the naked mole-rat (NMR), was assessed. NMRs are known for their long lifespans among rodents and for having low metabolic rates. We assessed long-term in vivo bone labeling of subordinate individuals, as well as the patterns of bone resorption and bone remodeling in a large sample including reproductive and non-reproductive individuals (n = 70).
Identifier
Format
Journal Article
URL Address
Pages
81-100
Issue
1
Volume
239
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pharmaceutical Sciences
Update Year & Number
Jan to Aug list 2021
Citation
Montoya-Sanhueza G;Bennett NC;Oosthuizen MK;Dengler-Crish CM;Chinsamy A, “Bone remodeling in the longest living rodent, the naked mole-rat: Interelement variation and the effects of reproduction.,” NEOMED Bibliography Database, accessed February 11, 2025, https://neomed.omeka.net/items/show/11800.