The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke.

Title

The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke.

Creator

Saralkar P; Mdzinarishvili A; Arsiwala TA; Lee Y; Sullivan PG; Pinti MV; Hollander JM; Kelley EE; Ren X; Hu H; Simpkins J; Brown C; Hazlehurst LE; Huber JD; Geldenhuys WJ

Publisher

Pharmaceutical Research

Date

2021
2021-05-12

Description

Therapeutic strategies to treat ischemic stroke are limited due to the heterogeneity of cerebral ischemic injury and the mechanisms that contribute to the cell death. Since oxidative stress is one of the primary mechanisms that cause brain injury post-stroke, we hypothesized that therapeutic targets that modulate mitochondrial function could protect against reperfusion-injury after cerebral ischemia, with the focus here on a mitochondrial protein, mitoNEET, that modulates cellular bioenergetics.

Subject

In this study, we evaluated the pharmacology of the mitoNEET ligand NL-1 in an in vivo therapeutic role for NL-1 in a C57Bl/6 murine model of ischemic stroke.

Format

Journal Article

URL Address

http://doi.org/10.1007/s11095-021-03046-4

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Integrative Medical Sciences

Update Year & Number

Jan to Aug list 2021

Citation

Saralkar P; Mdzinarishvili A; Arsiwala TA; Lee Y; Sullivan PG; Pinti MV; Hollander JM; Kelley EE; Ren X; Hu H; Simpkins J; Brown C; Hazlehurst LE; Huber JD; Geldenhuys WJ, “The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke.,” NEOMED Bibliography Database, accessed September 15, 2024, https://neomed.omeka.net/items/show/11910.